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Developing and refining orthotopic syngeneic and autochthonous in vivo models, together with ex vivo platforms such as organoids and tissue slice cultures that incorporate immune cells (27,28), should accelerate our understanding of tumor-immune interaction and responses to immune checkpoint and combination immunotherapies

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This difference matters because it means cagrilintide can suppress appetite through a separate signaling route than GLP-1s, which is exactly why researchers are largely testing it alongside semaglutide, rather than as a replacement for it